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VU 0469650
CAS No. 1443748-47-7
VU 0469650( —— )
Catalog No. M34469 CAS No. 1443748-47-7
VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 93 | Get Quote |
|
| 5MG | 121 | Get Quote |
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| 10MG | 183 | Get Quote |
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| 25MG | 357 | Get Quote |
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| 50MG | 533 | Get Quote |
|
| 100MG | 772 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVU 0469650
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NoteResearch use only, not for human use.
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Brief DescriptionVU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
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DescriptionVU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.
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In Vitro——
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In VivoVU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour.VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples.
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorGluR
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Research Area——
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Indication——
Chemical Information
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CAS Number1443748-47-7
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Formula Weight364.48
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Molecular FormulaC22H28N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=O)(C12CC3CC(C1)CC(C2)C3)N4[C@H](C)CN(CC4)C5=C(C#N)N=CC=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lovell KM, Felts AS, Rodriguez AL, et al. N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013;23(13):3713-3718.?
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